We repeated the same chemistry tests and statistical analysis on these 40 samples ( Table 1). On day 32, we collected serum samples from all 40 rats, after a 24hr fast, immediately after they were euthanized. There was no statistical difference between the two groups (N=8, P >0.1). Initially, we conducted chemistry tests with a comprehensive metabolic profile (total of 30 items tested) in a total of 8 serum samples collected at day 7 from 4 rats in groups 2 (High DIM) and 3 (no DIM). By accomplishing this, we will be able to fill a gap in the literature regarding the safety of this drug in this patient population. Our goal in this study is to determine if oral DIM is a safe drug for young rats, and if DIM poses a greater risk in immature rats when compared to mature ones. In this study, we conducted a safety feasibility experiment in sexually immature rats by collecting blood and tissue samples to screen for possible side effects. There is minimal evidence in the literature to show its safety in children, in whom this disease process can be the most devastating. However, current evidence to support its safety is mostly based on adult human or mature animal studies. 3,3′-diindolylmethane (DIM), a natural product from cruciferous vegetables, has been shown to be a dietary component that has such inhibitory effects on some cancers as well as recurrent respiratory papilloma (RRP). It is a well accepted fact that many human cancers could be prevented or reduced by changing lifestyle, including dietary modification. Unfortunately, currently used agents have significant side-effects. Cancer chemoprevention/therapy is a promising approach to fight tumors.
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